| 1 | Avatar | £4,865,081 | £65,070,599 |
| 2 | Alvin and the Chipmunks II | £1,195,220 | £19,953,194 |
| 3 | Edge of Darkness | £1,172,927 | £1,172,927 |
| 4 | Sherlock Holmes | £1,149,268 | £23,178,097 |
| 5 | It's Complicated | £849,416 | £7,093,321 |
| 6 | Up in the Air | £735,463 | £4,635,071 |
| 7 | Toy Story 2 | £690,291 | £1,832,385 |
| 8 | The Book of Eli | £484,983 | £3,521,900 |
| 9 | Precious | £260,921 | £260,921 |
| 10 | Daybreakers | £238,840 | £3,964,589 |